Warning: Too Much Chemo or Radiation Can Kill You!
English: Cancer cells photographed by camera attached to microscope in time-lapse manner. (Photo credit: Wikipedia)
Did you know that chemotherapy and radiation can cause cancer cells to mutate and become resistant to treatment? Worse, too much toxic burden from these treatments can destroy your immunity, so you could die from infections or complications.
For alternatives to chemo and radiation, see researched on Graviola.
Dr. David Sinclair:
A Leading Molecular Geneticist from Harvard University
Experience the Power of Graviola and Resveratrol !!!
“Holy Grail” of the Pharmaceutical Industry”
Slow Aging Clock by up to 50%
Charlie Rose Interview with Dr. David Sinclair showing how chimpanzee extends the life by 50%
Prevent, Manage and Fight Cancer
It selectively hunts down and kills 12 different types of cancer cells (without harming healthy cells) including breast, prostate, lung, colon, and pancreatic cancer. Be 10,000 times stronger in killing colon cancer cells than Adriamycin (a commonly used chemotherapeutic drug). Additionally, it actually boosts your immune system making the patient feel healthier and stronger and improves overall energy and outlook on life.
The Ultimate Antioxidant
Treatment and Prevention of Cancer Extend your life by 30% to 50% more!!!
100+ Reasons to take Gravitrol
Based on Harvard Scientist Dr. David Sinclair, Health Science Institute and Third Party Publish Report.
- Turn Off the Aging Clock and Extend Your Longevity – Trans-Resveratrol- It’s a molecule so tiny it penetrates the wall of almost any cell in a body. It continues into the cell nucleus, up to the cell’s genetic machinery. There Resveratrol selectively switch on genes that aid the survival of an organism, which is Sirtuin 1 DNA-repair gene. Using gene silencing, it switches off genes involved in the initiation and progression of disease, blocking replication of bacteria, viruses, fungi and tumor cells. It slows the onset of virtually all of the aging diseases
- Increase your Energy and Strength – Taps into your body’s natural life-giving force, unleashing vitality, energy, strength and stamina. It can literally add years to your life.
- Look and Feel Younger – Your body’s 10 trillion cells are under constant attack by free radicals. These harmful environmental agents can accelerate aging by destroying vital body cells faster than they can be replaced. Resveratrol is known to be the most powerful antioxidant depends against premature aging, fighting free radical damage throughout the body.
- Strengthen Your Heart – It helps to maintain the strength and integrity of coronary arteries. Prevented your blood platelets from sticking together, it also prevent strokes. Another way it powers your heart involves a miraculous capability called “anglo-genesis” a fancy term for blood vessels to deliver more oxygen to your heart when it’s not getting enough.
- Maintain Healthy Blood Pressure – Nearly one in four adults has high blood pressure (hypertension). Uncontrolled high blood pressure can lead to stroke, heart attack, heart failure or kidney failure. This is why high blood pressure is often called the “silent killer”. A researched study showed Resveratrol can normalise high blood pressure.
- Maintain Healthy Cholesterol Level – Keep cholesterol from oxidizing and forming arterial plaque, drives down levels of bad fats called triglycerides, These are the fatty acids that clog your arteries, it help to keep your arteries open and functioning smoothly. Reduces the harmful effects of bad cholesterol.
- Prevent Cancer- Can halt the genetic mutations that can lead to cancer. Your body is protected due to the compound called “acetogenins” these are superb inhibitors of Cancer cells.
- Manage and Fight Cancer – Effectively target and kill malignant cells in 12 different types of cancer, including colon, breast, prostate, lung,and pancreatic cancer. •• Its 10,000 times stronger in killing cancer cells than Adriamycin a commonly used Chemotherapy drug. •• Selectively hunt down and kill cancer cells without harming healhty cells, unlike Chemotherapy. •• Conquer cancer safely and effectively with an all-natural therapy that doesn’t cause extreme nausea, weight loss, and hair loss. •• Protect your immune system and evade deadly infections. •• Feel stromg and healthy throughout the course of treatment. •• Boost your energy and improve your outlook on life.
- Promotes Normal Blood Sugar and Manage Diabetes – It has been used in Europe and Sirtris Pharmaceutical in early trials and has significantly treat diabetes and Balance blood sugar and insulin response.
- Help You Maintain Weight and Prevent Obesity – It helps maintain your weight even with high fat diet; you can eat whatever you want without sacrificing your slim and lean body
- Strengthen Your Muscles and Bones – It turns out to be what spinach was for popeye. Study show it turned mice into Mighty Mice, granting them extraordinary strenth and stamina, they ramped up their aerobic capacity, lengthened their running time, and burned more oxygen and also noticed that it enhanced their muscles and bones.
- Enhance Sexual Function – It’s one of the most effective sexual tonic compound, it increases your strength during sex, studies show it increases your testosterone in the blood, thereby increasing libido and sperm count in both men and Women.
- Maintain Good Blood Circulation – In one study, it caused the blood of older people to revert to astonishing younger state due to the increased of oxygen level in the body.
- Improved Disease Resistance – Sirtuin 1 DNA-repair g ene. Using gene silencing, it switches off genes involved in the initiation and progression of disease, blocking replication of bacteria, viruses, fungi and tumor cells. It slows the onset of virtually all of the aging diseases.
- Improve Immune Response – The immune system is your body’s “armed forces” more than hundreds of researched shows the ability to regulate immunity by commanding and controlling many of the body’s important defense functions, it enhance and balance the activity of all classes of immune cells.
- Improved Your Vision – Studies show it helps bring back the clarity of blurred vision, it also help reduced the time it takes for vision to adapt to darkness, it also improved vision under subdued light, may also protect against macular degeneration and cataract.
- Protect Your Precious DNA – DNA is the most important chemical in our body, ensuring that – as they need replacement – your 10 trillion cells are faithfully reproduced as healthy, exact duplicates, Exposure to chemicals, pollutants, and free radicals can cause DNA damage and breakage, leading to genetic mutations, cancer and even death Resveratrol can restore and repair damaged DNA.
- Improve Fertility – Studies show it is good for the treatment of infertility in both men and women, It can restore the reproductive essence in women, it increases the sperm count in men.
- Improved Quality of Sleep – Graviola has long been used worldwide for the natural treatment of insomnia. In studies it gives you a calming effect and better quality of sleep.
- Fight Inflammation and Arthritis – In acute and chronic inflammation, the free radical superoxide is produced at a rate that overwhelms the capacity of the body’s SOD ensyme defense system to remove it. This imbalance results in pain and damage to joints and tissues. Gravitrol can restore the balance of the important anti-inflammatory SOD enzyme.
- Alleviate Anxiety and Stress – As an adaptogen, Gravitrol helps the body to adapt and cope with stress. It provides the energy reserves to help you handle just about any difficulty.
- Support Normal Kidney Function – The Kidney is the most important of all the vital organs, and they are believed to control the brain and other organs. Proper kidney function is considered to be essential to survival. Resveratrol has superb supertonic effect for kidney.
- Prevent Allergies – A study noted that Resveratrol reduced anti-bodies associated with allergic-typereactions, presumably through the mechanism of promoting CDB (+) T-Cells and regulating cylokines. It enhances cell-mediated and humoral immune responses, increasing normal activity of T-cells and natural killer cells.
- Inhibit Tumor Growth – Annonaceous Acetogenins in Graviola can selectively inhibit the growth of cancerous cell, tumor and also inhibit the growth of adriamycin resistant tumor cells.
- Stop Fungal and Bacterial Infection – Graviola has been used worldwide for the treatment of skin diseases
- Anticancerous & Antitumor Actions – Marshall, J. A., et al. “ABC synthesis and antitumor activity of a series of Annonaceous acetogenin analogs with a threo, trans, threo, trans, threo-bis-tetrahydrofuran core unit.” Bioorg. Med. Chem. Lett. 2007 Feb 15;
- Antimicrobial Actions – Takahashi, J.A., et al. “Antibacterial activity of eight Brazilian Annonaceae plants.” Nat. Prod. Res. 2006; 20(1): 21-6
- Antidepressant & Antistress Actions – Padma, P., et al. “Effect of Annona muricata and Polyalthia cerasoides on brain neurotransmitters and enzyme monoamine oxidase following cold immobilization stress.” J. Natural Remedies 2001; 1(2): 144–46.
- Hypotensive & Cardiodepressant Actions – Carbajal, D., et al. “Pharmacological screening of plant decoctions commonly used in Cuban folk medicine. ” J. Ethnopharmacol. 1991; 33(1/2): 21–4.
- Anticonvulsant, Antispasmodic, & Insecticidal Actions – N’gouemo, P., et al. “Effects of ethanol extract of Annona muricata on pentylenetetrazol-induced convulsive seizures in mice.” Phytother. Res. 1997; 11(3): 243–45.
- Antiparasitic, Antimalarial, & Insecticidal Actions – Osorio, E., et al. “Antiprotozoal and cytotoxic activities in vitro of Colombian Annonaceae. J. Ethnopharmacol. 2007 Jan 18;
- Improve Digestion – >Graviola has been used in the treatment of atropic gastritis, a weakening of digestion caused by reduced activity of stomach cells.
- Help Chronic Dry Cough – Graviola is used by the natives of the amazon as a decongestant to treat cough and colds.
- Cure lice – Luna, J. S., et al. “Acetogenins in Annona muricata L. (Annonaceae) leaves are potent molluscicides. ” Nat. Prod. Res. 2006; 20(3): 253-7.
- Expels Worms – Jaramillo, M. C., et al. “Cytotoxicity and antileishmanial activity of Annona muricata pericarp.” Fitoterapia. 2000; 71(2): 183–6.
- Treat Diarrhea – Betancur-Galvis, L., et al. “Antitumor and antiviral activity of Colombian medicinal plant extracts.” Mem. Inst. Oswaldo Cruz 1999; 94(4): 531-35
- Treat Gall-Bladder – Feng, P. C., et al. “Pharmacological screening of some West Indian medicinal plants.” J. Pharm. Pharmacol. 1962; 14: 556–61.
- Treat Ashma – Hasrat, J. A., et al. “Screening of medicinal plants from Suriname for 5-HT 1A ligands: Bioactive isoquinoline alkaloids from the fruit of Annona muricata.” Phytomedicine. 1997; 4(20: 133-140.
- Treat Dyspepsia – Meyer, T. M. “The alkaloids of Annona muricata.” Ing. Ned. Indie. 1941; 8(6): 64.
- Treat Flu – Feng, P. C., et al. “Pharmacological screening of some West Indian medicinal plants.” J. Pharm. Pharmacol. 1962; 14: 556–61.
- Treat Rheumatism – Graviola has been used by the amazon native for hundreds of year to treat rheumatism.
- High Fever – Carbajal, D., et al. “Pharmacological screening of plant decoctions commonly used in Cuban folk medicine.” J. Ethnopharmacol. 1991; 33(1/2): 21–4.
- Preserves or Stimulates Superoxide Dismutase (Antioxidant) – J Agriculture Food Chemistry 2005 May 18; 53(10):4182-6; Free Radical Biology Medicine 2003 Apr 1; 34(7):810-7
- Elevates glutathione (antioxidant) – J Agric Food Chem. 2005 May 18; 53 (10):4182-6; Archives Biochemistry Biophysics 2000 Sep 15; 381 (2):253-63
- Elevate Catalase Activity (Antioxidant) – Life Science 2003 May 2; 72 (24):2741-50
- Anti-histamine action (allergy) – Planta Medica 2004 Apr;70(4):305-9,
- Anti-inflammatory agent – Toxicology Oncology 2004; 23(3):215-26
- COX-2 inhibitor (anti-inflammatory) – Inflammation Research 2005 Apr; 54(4):158-62
- Potentially helpful for rheumatoid arthritis – International Immunopharmacology 2005 May;5(5):849-56
- Promotes DNA repair (via Sirtuin 1 gene) – Nature 2003 Sep 11; 425 (6954):191-6
- Inhibits abnormal new blood vessel formation (angiogenesis) – J Physiology Pharmacology 2005 Mar;56 Supp11:51-69
- Inhibits dietary sugar absorption – Journal Natural Products 2001; 64:381-84
- Regulates blood sugar – J Agric Food Chemistry 2005 May 4; 53(9):3403-7
- Normalizes blood pressure – J Hypertension 2000 Dec; 18(12): 1833-40
- ACE Inhibitor properties – European J Pharmacology 2005 May 16; 515(1-3): 1-9
- Prevents blood clots – Blood Coagulation Fibrinolysis 2004 Sep;15(6):441-6
- Reduces LDL cholesterol – Life Sciences 2003 Aug 1; 73(11):1393-400
- Reduces triglycerides – Life Sciences 2003 Aug 1; 73(11): 1393-400
- Raises HDL “good” cholesterol – J Agric Food Chemistry 2005 May 4; 53(9):3403-7
- Inhibits arterial plaque w/o altering cholesterol – IntJMol Med. 2005 Oct;16(4):533-40.
- Calms effects of estrogen (estrogen blocker) – J Steroid Biochemical Mol Biology 2005 Apr;94(5):431-43
- Prevents bone loss – J Medicinal Food 2005 Spring;8(1):14-9
- Protects retinal cells (retinal pigment epithelium) – Chemical Biological Interaction 2005 Jan 15; 151(2): 143-9
- Increases sperm count – J Nutrition 2005 Apr; 135(4) :757-60
- Inhibits viral growth (influenza) – J Infectious Disease 2005 May 15; 191 (10): 1719-29
- Inhibits viral growth (HIV) – J Pharm Science 2004 Oct; 93 (10):2448-5
- Inhibits viral growth (herpes) – Antiviral Research 2004 Jan;61(1);19-26; 1999 Oct;43(3): 145-55
- Antibiotic against bacteria (Chlamydia) – Atherosclerosis 2003 Dec;171(2):379-80
- Antibiotic against bacteria (H. pylori) – Am J Gastroenterology 2003 Jun;98(6):1440-1
- Inhibits growth of fungi (yeast, mold) – J Agriculture Food Chemistry 2003 Feb 26:51 (5): 1464-8
- Inhibits initiation of tumors – Proc NatI Sci Counc Repub China B. 1999 Jul;23(3):99-106
- Inhibits growth of tumors 2 – Drugs Experimental Clinical Research 1999:25(2-3):65-77
- Inhibits spread of tumors 3 – Proc NatI Sci Council Repub China B. 1999 Jul;23(3):99-106
- Targets multiple genes (silencing/activation) –I J Nutritional Biochemistry. 2005Aug;16(8):449-66
- Protects brain cells – Ann N Y Academy Sciences 2003 May;993:276-86
- Inhibits hepatitis (liver inflammation)____ – I Hepatogastroenterology 2002 Jul-Aug;49(46):1102-8
- Eradicates plaque in brain (beta amyloid toxicity) – British J Pharmacology 2004 Mar;141 (6):997-1005
- Chelates metals (copper)_________ – Biochem Pharmacology 1997 May 9; 53(9): 1347-55
- Anti-leukemia agent__________ – Leukemia Lymphoma 2002 May;43(5):983-7
- Inhibits prostate cancer – Cancer Epidemiology Biomarkers Prevention 2005 Mar;14(3):596-604
- Inhibits breast cancer – Molecular Nutrition Food Research 2005 May;49(5):462-71
- Inhibits melanoma – I Neoplasia2005Jan;7(1):37-47
- Inhibits liver cancer – World J Gastroenterology 2003 Oct;9(10):2341-3
- Inhibits brain cancer – [Molecular Cancer Therapy 2005 Apr;4(4):554-61
- Inhibits pancreatic cancer – Pancreas 2002 Nov;25(4):e71-6
- Inhibits kidney cancer – Cancer Biology Therapy 2004 Sep; 3(9):882-8
- Inhibits colon cancer – International J Cancer. 2005 Jun 10; 15(2): 194-201
- Inhibits ovarian and cervical cancer – Anticancer Res. 2004 Sep-ct;24(5A):2783-840.
- Inhibits lymphoma – Cancer Letters 2001 Feb 10,163(1 ):43-9
- Exhibits Viagra-like effects (nitric oxide) – Free Radical Biology Med. 2004 Mar 15;36(6):774-81
- Novel molecule for organ transplants – World J Gastroenterology. 2005 Aug 14;11(30):4745-9
- Non-toxic – J Nutrition 2002 Feb;132(2):257-60
- Heart Palpitation – Carbajal, D., et al. “Pharmacological screening of plant decoctions commonly used in Cuban folk Medicine. “J. Ethnopharmacol. 1991; 33(1/2): 21-4
- Nervousness – Meyer, T. M. “The alkaloids of Annona muricata.” Ing. Ned. Indie. 1941; 8(6): 64.
- Dysentery – Sundarrao, K., et al. “Preliminary screening of antibacterial and antitumor activities of Papua New
- Malaria – Antoun, M. D., et al. “Screening of the flora of Puerto Rico for potential antimalarial bioactives.” Int. J. Pharmacog. 1993; 31(4): 255–58.
- Stomach Ulcer – Padma, P., et al. “Effect of alcohol extract of Annona muricata on cold immobilization stress induced tissue lipid peroxidation.” Phytother. Res. 1997; 11(4): 326-327.
- Skin Dermatosis – Padma, P., et al. “Effect of the extract of Annona muricata and Petunia nyctaginiflora on Herpes simplex virus.” J. Ethnopharmacol. 1998; 61(1): 81–3.
- Scurvy – Misas, C. A. J., et al. “Contribution to the biological evaluation of Cuban plants. IV.” Rev. Cubana Med. Trop. 1979; 31(1): 29–35.
- Help Remove Fatty Liver – World J Gastroenterology 2003 Oct;9(10):2341-3
- Reduce the Incidence of Coronary Heart Disease – IntJMol Med. 2005 Oct;16(4):533-40
- Protect from the Negative Effect of High Fat Diet – I J Nutritional Biochemistry. 2005Aug;16(8):449-66
- Stop Virus – Stop Herpes – Antiviral Research 2004 Jan;61(1);19-26; 1999 Oct;43(3): 145-55
- Protect the Brain Against Oxidative Stress-Keeping Cells Alive – Ann N Y Academy Sciences 2003 May;993:276-86
- Protect Against Ischemia, Referfusion, Induced Arrhythmias and Mortality – Biochem Pharmacology 1997 May 9; 53(9): 1347-55
- Increase the Number of Energy Generating Mitochondria in Muscles Cells – Trends Pharmacological Sciences 2005; 26:94-103
List of References
“Experience the power of Graviola and Resveratrol”
- National Cancer Institute
- Journal of Medicinal Chemistry
- Purdue University published information
- Harvard School of Medicine
- Ray Sahelian, M.D.HEALTH SCIENCES INSTITUTE
- Skaggs Scientific Report 1997-1998
- Herbal Secrets of the Rainforest by Leslie Taylor
- Medicine From the Rainforest – GraviolaBy Dr. Robert D. Willix, Jr.
- Health & Longevity Newsletter, March 2003, Vol. 10, No. 3
- A service of the U.S. National Library of Medicineand the National Institutes of Health
- United States Department of Agriculture
- Agricultural Research Service, Beltsville Area
- Germplasm Resources Information Network (GRIN)
Since the introduction of (Resveratrol) in January 2006, we have been inundated with testimonials from our users.
We thought (Resveratrol) would help maintain healthy cholesterol levels. However, we were totally surprised by all the other ailments which (Resveratrol) has helped with! Read below to find out just a few…
Shirley B. St. Louis, Missouri
“Since taking the Resveratrol, I have had more energy, my good cholesterol (HDL) is 94 and my vision has improved so much that I am not wearing my glasses at all.” (Fall 2007)
Ellen W. Hot Spr Village, Arkansas
“I began taking Resveratrol per day in late 2006. I made no change in diet, lifestyle, or exercise. I am not taking any lipd-lowering medications or other supplements. My baseline cholesterol has dropped from 300+ to 210, and triglycerides from 700+ to 185.” (March 2007)
Etta B. Plaucheville, Louisiana
“I started taking Resveratrol 6 months ago. I feel much better with my circulation. I had floaters in both eyes and macular degeneration. I went for a check-up on my eyes. I no longer have floaters and the macular degeneration is doing better. Thanks to Resveratrol.” (May 2001)
Barbara B. and daughter Natchez, Mississippi
“Thirty years ago I broke a kneecap which has given me trouble ever since. After two weeks of taking Resveratrol, I noticed a big change in my knee; it was not tight feeling anymore! It seems like my knee has been lubricated. 3 months later, I put my daughter on resveratrol as she has had infected toenails for 2 years.
However, after 3 weeks of taking Resveratrol she had a completely well toe for the first time.” (March 1999)
Brenda M. Natchez, Mississippi
“I have rheumatoid arthritis. I started taking Resveratrol 3 times a day for a week. Now I’m only taking it once a day. I’ve had no pain or stiffness since I started taking it and as long as I don’t forget to take it!” (May 2000)
John V. Hammond, Louisiana
“My knees had hurt me for several years. After taking Resveratrol pills for two weeks (3 times per day), my knees do not hurt me anymore. I cannot say enough good about Resveratrol pills.” (April 2001)
Pete J. Prairieville, Louisiana
Pete began taking Resveratrol in January 1998. Resveratrol helped me with a couple of things. I’ve had acne all my life, and I am now free of the acne. Plus, I feel great! I told a pharmacist friend of mine about the capsules, and he now takes them and has some of his customers taking them, particularly men with prostate.” Problems (March 1999)
Louise K. Millington, Tennessee
Louise has an unknown condition that has affected her legs and feet. “I couldn’t walk. I was put into casts and various orthopedic devices, none of which helped. In fact, my condition deteriorated so that I could not stand on my feet and walk. I began taking 3 capsules per day, but now I take 2 per day. I know that I am able to walk better now, and I’m about 1,000% better than I was. I now have excellent circulation in my feet! And, my total cholesterol has dropped from 267 to 164 within one year, with my good cholesterol higher than the bad cholesterol!” (March 1999)
Myrtle M. Natchez, Mississippi
A hairdresser who takes 1 capsule per day. “I feel like I have new hands when I take resveratrol otherwise she would find work very difficult due to arthritis in her hands. (April 1999)
Ray S. Natchez, Mississippi
“In 1991 I decided to ride a bicycle from Natchez to Jackson on the Natchez Trace Parkway. I injured my left knee and was in pain until the summer of 1998 when I began taking Resveratrol. I was real skeptical about the capsules and initially took 1 capsule only occasionally, but when I saw the good results that other people experienced from taking them regularly, I began taking 3 capsules a day. Within a few days I could tell the difference and am now pain free in my knee.” (March 1999)
Olma B. Houston, Texas
Following a stroke, Olma was unable to read and her mobility was limited to using a wheelchair or walker. Her son took her some Old South muscadine wine and Resveratrol capsules to take. Soon she began reading again and even walking! In fact, in November 1998, she walked into the Winery to show everyone how great she feels and how well she can now read! (February 2007)
Becky W. Natchez, Mississippi
A former realtor who had to retire due to arthritis. After 1 week of taking 2 capsules/day she could make a fist for the first time in 2 years. “It feels like I squirted WD-40 in all my joints!” (March 2006)
Mary & Kenneth A. Natchez, Mississippi
Following years of insulin diabetes, Mary had difficulty controlling her blood sugar level, was exhausted most of the time, and couldn’t think straight. Kenneth, her husband, bought her some resveratrol and she began taking 1 each morning and evening. “It made me feel real good. I was more alert, my head was clearer. It helps keep my blood sugar level even.” Kenneth, a barber, also takes Resveratrol. “I’m sure it helps the immune system. I’m around a lot of people all the time, but I haven’t been sick this winter.” (March 2007)
Bobbie J. Plano, Texas
Due to severe rheumatoid arthritis in her hands, Bobbie had to quit hand quilting and many other activities. Initially, she took 2 capsules daily for two weeks, then decided to increase her dosage to 3 capsules. After four days at the increased dosage, she could close her hand for the first time in years. (September 2007)
Lloyd J. Houston, Texas
Lloyd, a long-time high school football coach, was told that he needed knee replacement surgery after trying every imaginable non-surgical treatment and he had severe arthritis pain in his wrist. He is now pain-free in his knees and wrist as long as he takes two Resveratrol daily. (April 2007)
I had skin cancer removed from my chest, but still had spots on my face, nose,ears and shoulder. After taking one and a half bottles of Graviola, the marks have faded and shrunk quite noticeably. I had blemishes on my hands which have cleared up. I am a very happy man and will continue using a maintenance dose to hopefully prevent any more problems with my skin.
I’m very happy to write and tell you that my prostate cancer has just about gone. Having been on Graviola Extract now since January 2005. Went to the doctor back in February 3rd, 2005 my PSA reading was a high of 26 down from 32. I\’m very, very happy to say taht I took another PSA reading May 29th, 2005 and my PSA was 0.6. Yes, I almost fell out of the chair. I owe it all to Graviola Extract. To say the least my doctor was very happy and suprise that it was that low. I will be taking another reading sometime in July to see if it still low. I feel so much better, physically and mentally. It feels so great knowing I don\’t have to take chemo. Thanks to Graviola Extract. Take it now for preventatives reasons…
My name is Peter and on Aug. 9, 2004 I found out that I had Lymphoma Cancer. During the next 6 months I had 8 chemo treatments, I also found out about Graviola and started to take it at the same time. At one time the Doctor wanted to increase the Chemo dosage but due to conditions couldn’t. Since my last treatment I have had 3 scans and all have shown no signs of Cancer. I still take the Graviola and the Immune Boom, which is a Lymphatic booster cleaner, every day to stay fit. I am now back to work full time and feel quite well. I think that the Graviola and Immune Boom played a big part in my recovery. Thank you for introducing me to the product.
I am writing to submit my testimonial and the experience I’ve just recently gone through with Graviola. In August of 2004 I was diagnosed with Cervical Cancer. I began the steps of tests and trips to the specialist to see how they wanted to treat the disease. After my first visit to Princess Margaret Hospital in Toronto they were getting me prepared for radiation and chemotherapy. I felt like the wind was knocked out of my sails. A couple of weeks after my diagnosis, my father gave me some information and some Graviola to try. I felt why not, it can’t hurt, it’s all natural, it comes from God’s great earth so it can’t be all that bad. I noticed within a day or so my energy level had increased and I felt much stronger physically. When I went for my MRI in November the Doctors basically said that I had a very bazaar type of cervical cancer and they wanted to treat it aggressively. The MRI showed that I had a cancerous tumor and that it was showing growth within my lymph nodes. The decision was made to remove the cancerous tumor surgically. They booked me for a radical hysterectomy right away. Prior to my surgery I continued to take the Graviola. The surgery went well and they were able to remove the tumor. The pathology reports after the surgery showed that the tumor had shrunk extensively and that they were showing NO CANCEROUS activity in the lymph nodes. My response to this was overwhelming as you can imagine. This is a direct result of the GRAVIOLA and the many people praying on my behalf. Hope this helps someone make the right decision and try this product.
It saved my life, I continue to take this product for preventative reasons. Strong and cancer free !!
I was diagnosed with Melanoma skin cancer in April, 04. I had surgery on my ear to remove the cancer and they warned me that it would return. In November, I heard about Graviola and began taking it. Soon afterward, my doctor examined me and found cancerous nodes in my neck. I was booked for a radical neck dissection in Feb.05. Meanwhile I continued taking Graviola and Immune Boom as well. To the surgeon`s surprise, the cancer was reduced to one lymph gland only, so had not spread and the surgery was much shorter than expected. Also, the Oncologist in London was very surprised that I only stayed in hospital for 3 days and had a quick recovery with no infection ! They asked me to stop all supplements, including Graviola and Immune Boom for 2 weeks prior to surgery. I noticed a marked difference. During that time my energy level dropped dramatically and I felt mentally down. After surgery, I resumed my Graviola and Immune Boom and immediately felt much better, physically and mentally ! The Oncologist in Kitchener talked about radiation, but the surgeon said I didn`t need it. I feel so much better now and have my quality of life back thanks to Graviola and Immune Boom.
I’m not very good at writing testimonials but, will give it a try. I started taking Graviola Extract in January, have been on it for a month now and can feel the difference in my body. Went to the doctor on February 3rd, 2005 for my PSA reading and found out that it has fallen from a high of 31 to a low of 26. To say the least my doctor was very happy with that. I’m also feeling fine, full of energy and in a good mood since started taking Graviola Extract. Thank you for all your help and support. Today I just ordered 3 more bottles.
I have Lymphoma and have to go to Toronto for 8 more radiation treatments. My blood was so low last week that I needed several transfusions. After each radiation treatment I`d feel so nauseated and weak I couldn`t eat. I lost weight and have pain and stiff legs from the radiation. I can feel several lumps on my legs. I was introduced to Graviola, well, I was desperate, I decided to try it immediately. I started Graviola once a day [because of the nausea] and Immune Boom 3 times a day. Three days later, I took a radiation treatment and had no nausea. I was even able to return home and have some stew with my friends. This was a FIRST! I’m feeling better and have some more energy. Now I can increase my Graviola and won’t have to dread the remaining treatments! Others can’t believe the difference a few days of Graviola and Immune boom have made!
I lost my wife to cancer 1 ½ years ago. Last summer I wasn’t well. One day as I was driving alone I found myself struggling to breathe, so drove straight to the hospital. They admitted me immediately and discovered that I had pneumonia and also a large tumor in my right lung. Later that day, I was so weak I couldn’t even sit up without support. They wanted to operate and start chemo but I refused. The doctors thought I was in pretty bad shape. I decided to try Graviola for the Cancer and have been taking the extract 5 times a day since Oct. 12th. Last week I went to my family doctor and he was shocked that I looked so well. He examined me and was amazed that I could breathe so much better and wasn’t losing weight. Even more amazing is the fact that, at 74, I still get up at 5am and start work at 6am-often working 10-11 hours a day at my gas station. Also, every winter for the past 20 years I`d get scabs on my earlobe that were diagnosed as cancer. I`d pick them off and cause bleeding and they`d always grow back. Since taking Graviola , I no longer get the scabs forming. My ear is so clean, even with this last cold spell. I am so glad I began on Graviola and an immune booster as well. I feel better, have more energy and can breathe better than I have for the past 2 years. In January I`ll be tested again so we`ll see what the doctors think then.
Hi, I’m a 26 years old mother of 3 children. One year ago, I was diagnosed with cervical cancer at level 3 stage 2. My treatment included 2 injections of freezing that were ineffective, 2 sessions of external radiation lasting 6 weeks each and 2 sessions of internal radiation using rods. During this time I kept losing weight, lost my appetite and was badly burned from the radiation. I got kidney damage as well. I went down to 80 pounds then they stopped the last session of radiation and cancelled the upcoming chemo. I could hardly get out of bed and spent all my time on the couch. My husband quit his job to look after me. I was off radiation for over a month when I began taking Graviola. I have been on the Graviola for 3 weeks now, I am up and about and my energy has improved dramatically. I can even go out shopping for an hour, got my appetite back and have gained 10 pounds. I feel a lot better, a 100% better, I feel a lot less pain and sleep better since taking Graviola. I can smile again!
I’m most grateful for Graviola !
References on Graviola
de Feo, V. 1992. Medicinal and magical plants in the northern Peruvian Andes.
Vasquez, M. R., 1990 Useful Plants of Amazonian Peru. Second Draft. Filed with
USDA’s National Agricultural Library. USA.
Grenand, P., Moretti, C., Jacquemin, H., 1987. Pharmacopees taditionnels en
Guyane: Créoles, Palikur, Wayãpi. Editorial l-ORSTROM, Coll. Mem No. 108. Paris,
Branch, L.C. and da Silva, I.M.F. 1983. “Folk Medicine of Alter do Chao, Para, Brazil.”
Acta Amazonica 13(5/6):737-797.
de Almeida, E.R., 1993. Plantas Medicinais Brasileiras, Conhecimentos Populares E
Cientificos. Hemus Editora Ltda.: Sau Paulo, Brazil.
Asprey, GF. & Thornton, P. 1955. Medicinal Plants of Jamaica. III West Indian Med J
Ayensu, ES. 1978. Medicinal Plants of the West Indies. Unpublished manuscript:
110P-(1978) Office of Biological Conservation Smithsonian Institution, Washington,
Weniger, B. et.al., 1986. Popular Medicine of the Central Plateau of Haiti. 2.
Ethnopharmacological Inventory J Ethnopharmacol 17 1: 13-30 (1986).
Alali FQ, et.al., Annonaceous acetogenins: recent progress. J Nat Prod. 1999
Feng, P.C. et.al., Pharmacological Screening of Some West Indian Medicinal Plants.
J Pharm Pharmacol 14 : 556-561 (1962).
Meyer, TM. The Alkaloids of Annona Muricata. Ing Ned Indie 8 6: 64- (1941).
Carbajal, D., et.al., Pharmacological Screening of Plant Decoctions Commonly Used
in Cuban Folk Medicine. J Ethnopharmacol 33 1/2: 21-24 (1991).
Misas, CAJ et.al., Contribution to the Biological Evaluation of Cuban Plants. IV. Rev
Cub Med Trop 31 1: 29-35 (1979).
Sundarrao, K et.al., Preliminary Screening of Antibacterial and Antitumor Activities of
Papua New Guinean Native Medicinal Plants. Int J Pharmacog 31 1: 3-6 (1993).
Heinrich, M. et.al., Parasitological and Microbiological Evaluation of Mixe Indian
Medicinal Plants (Mexico) J Ethnopharmacol 36 1: 81-85 (1992).
Lopez Abraham AM, 1979 Plant extracts with cytostatic properties growing in Cuba.
I Rev Cubana Med Trop 31(2), 97-104 (1979).
Bories, C. et.al., Antiparasitic Activity of Annona Muricata and Annona Cherimolia
Seeds Planta Med 57 5: 434-436 (1991).
Antoun, MD. et.al., Screening of the Flora of Puerto Rico for Potentialantimalarial
Bioactives. Int J Pharmacog 31 4: 255-258 (1993).
Gbeassor, M., et.al., In Vitro Antimalarial Activity of Six Medicinal Plants. Phytother
Res 4 3: 115-117 (1990).
Hasrat JA, et al. Isoquinoline derivatives isolated from the fruit of Annona muricata
as 5-HTergic 5-HT1A receptor agonists in rats: unexploited antidepressive (lead)
products. J Pharm Pharmacol. 1997 Nov; 49(11): 1145-1149.
Unpublished Data, National Cancer Institute. Anon: Nat Cancer Inst Central Files –
(1976) from Napralert Files, University of Illinois, 1995.
Zeng L, et al. Five new monotetrahydrofuran ring acetogenins from the leaves of
Annona muricata. J Nat Prod. 1996 Nov; 59(11): 1035-1042.
Rieser MJ, et al. Five novel mono-tetrahydrofuran ring acetogenins from the seeds of
Annona muricata. J Nat Prod. 1996 Feb; 59(2): 100-108.
Wu FE, et al. Additional bioactive acetogenins, annomutacin and (2,4-trans and cis)
-10R-annonacin-A-ones, from the leaves of Annona muricata. J Nat Prod. 1995 Sep;
Wu FE, et al. New bioactive monotetrahydrofuran Annonaceous acetogenins,
annomuricin C and muricatocin C, from the leaves of Annona muricata. J Nat Prod.
1995 Jun; 58(6): 909-915.
Wu FE, et al. Muricatocins A and B, two new bioactive monotetrahydrofuran
Annonaceous acetogenins from the leaves of Annona muricata. J Nat Prod. 1995 Jun;
Wu FE, et al. Two new cytotoxic monotetrahydrofuran Annonaceous acetogenins,
annomuricins A and B, from the leaves of Annona muricata. J Nat Prod. 1995 Jun;
Rieser MJ, et al. Bioactive single-ring acetogenins from seed extracts of Annona
muricata. Planta Med. 1993 Feb; 59(1).
Rieser, M J. et.al. Muricatacin: a Simple Biologically Active Acetogenin Derivative
from the Seeds of Annona Muricata (Annonaceae). Tetrahedron Lett 32 9: 1137-
Kim GS, et al. Muricoreacin and murihexocin C, mono-tetrahydrofuran acetogenins,
from the leaves of Annona muricata. Phytochemistry. 1998 Sep;49(2):565-71.
Padma P, et al. Effect of the extract of Annona muricata and Petunia nyctaginiflora
on Herpes simplex virus. J Ethnopharmacol. 1998 May;61(1):81-3.
Gleye C, et al. cis-monotetrahydrofuran acetogenins from the roots of annona
muricata1. J Nat Prod. 1998 May;61(5):576-9.
Kim GS, et al. Two new mono-tetrahydrofuran ring acetogenins, annomuricin E and
muricapentocin, from the leaves of Annona muricata. J Nat Prod. 1998
K.L. Mikolajczak, J.L. McLaughlin, and J.K. Rupprecht, “Control of Pests with
Annonaceous Acetogenins,” (pesticidal use patent on acetogenins) U.S. Patent No.
4,721,727, issued January 26, 1988.
J.L. McLaughlin, Z.-M. Zu, and G.-X. Zhao, “Bioactive Acetogenins and Derivatives,”
(Protects several new structures), U.S. Patent No. 5,536,848, issued July 16, 1996
(International Serial No. PCT/US95/07490, international date June 13, 1995).
D.C. Hopp and J.L. McLaughlin, “Use of Selectively Cytotoxic Annonaceous
Acetogenins,” filed February 4, 1997, P-97006.00 U.S.
D.C. Hopp and J.L. McLaughlin, “Annonaceous Acetogenins Selectively Cytotoxic
Against Pancreatic Tumors,” filed February 17, 1997, P-97019.00 U.S.
N.H. Oberlies and J.L. McLaughlin, “Use of Annonaceous Acetogenins to Treat
Multidrug Resistant Tumors,” disclosed to Purdue Research Foundation, February 17,
J.L. McLaughlin, F.Q. Alali, W. Kaakeh, and G.W. Bennett, “Use of Annonaceous
Acetogenins against Pesticide-Resistance,” disclosed to Purdue Research Foundation,
October 15, 1997, P-97059.00. US.
References on Resveratrol
- ^ Farina A, Ferranti C, Marra C (2006). “An improved synthesis of resveratrol”. Nat. Prod. Res. 20 (3): 247–52. doi:10.1080/14786410500059532. PMID 16401555.
- ^ “Potentially Universal Mechanism Of Aging Identified”. http://www.sciencedaily.com. Retrieved on 2008-11-28.
- ^ a b Elliott PJ, Jirousek, M. (2008). “Sirtuins: Novel targets for metabolic disease”. Current Opinion in Investigational Drugs 9 (4): 1472–4472. PMID 18393104.
- ^ Renaud S, Ruf JC (1994). “The French paradox: vegetables or wine”. Circulation 90 (6): 3118–9. PMID 7994864.
- ^ Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, Scherer B, Sinclair DA (2003). “Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan” (PDF). Nature 425 (6954): 191–196. doi:10.1038/nature01960. PMID 12939617. http://www.fiestaterrace.com/dlamming/nature2003.pdf.
- ^ Wood JG, Rogina B, Lavu1 S, Howitz K, Helfand SL, Tatar M, Sinclair D (2004). “Sirtuin activators mimic caloric restriction and delay aging in metazoans” (PDF). Nature 430 (7000): 686–9. doi:10.1038/nature02789. PMID 15254550. http://sinclairfs.med.harvard.edu/pdfs/nature2004.pdf.
- ^ Gruber J, Tang SY, Halliwell B (April 2007). “Evidence for a trade-off between survival and fitness caused by resveratrol treatment of Caenorhabditis elegans”. Ann N Y Acad Sci. 1100: 530–42. doi:10.1196/annals.1395.059. PMID 17460219.
- ^ a b Bass TM, Weinkove D, Houthoofd K, Gems D, Partridge L. (2007). “Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans”. Mechanisms of ageing and development 128 (10): 546–52. doi:10.1016/j.mad.2007.07.007. PMID 17875315.
- ^ Pearson KJ, et al. (2008). “Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span”. Cell Metab 8 (2): 157–68. doi:10.1016/j.cmet.2008.06.011. PMID 18599363.
- ^ Valenzano DR, Terzibasi E, Genade T, Cattaneo A, Domenici L, Cellerino A (2006). “Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate”. Current Biology 16 (3): 296–300. doi:10.1016/j.cub.2005.12.038. PMID 16461283.
- ^ Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy S, Fishbein KW, Spencer RG, Lakatta EG, Le Couteur D, Shaw RJ, Navas P, Puigserver P, Ingram DK, de Cabo R, Sinclair DA (2006). “Resveratrol improves health and survival of mice on a high-calorie diet”. Nature 444 (7117): 337–42. doi:10.1038/nature05354. PMID 17086191.
- ^ a b c d See review:Baur JA, Sinclair DA (2006). “Therapeutic potential of resveratrol: the in vivo evidence”. Nat Rev Drug Discov 5 (6): 493–506. doi:10.1038/nrd2060. PMID 16732220.
- ^ a b c d e f g See review:Athar M, Back JH, Tang X, et al (November 2007). “Resveratrol: a review of preclinical studies for human cancer prevention”. Toxicol. Appl. Pharmacol. 224 (3): 274–83. doi:10.1016/j.taap.2006.12.025. PMID 17306316.
- ^ Resveratrol. From Clinicaltrials.gov. Retrieved August 15, 2008.
- ^ a b Boocock DJ, Faust GE, Patel KR, et al (June 2007). “Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent”. Cancer Epidemiol. Biomarkers Prev. 16 (6): 1246–52. doi:10.1158/1055-9965.EPI-07-0022. PMID 17548692.
- ^ Niles RM, Cook CP, Meadows GG, Fu YM, McLaughlin JL, Rankin GO (October 2006). “Resveratrol is rapidly metabolized in athymic (nu/nu) mice and does not inhibit human melanoma xenograft tumor growth”. J. Nutr. 136 (10): 2542–6. PMID 16988123. PMC: 1612582. http://jn.nutrition.org/cgi/pmidlookup?view=long&pmid=16988123.
- ^ Wenzel E, Soldo T, Erbersdobler H, Somoza V (May 2005). “Bioactivity and metabolism of trans-resveratrol orally administered to Wistar rats”. Mol Nutr Food Res 49 (5): 482–94. doi:10.1002/mnfr.200500003. PMID 15779067.
- ^ Gao X, Xu YX, Divine G, Janakiraman N, Chapman RA, Gautam SC (July 2002). “Disparate in vitro and in vivo antileukemic effects of resveratrol, a natural polyphenolic compound found in grapes”. J. Nutr. 132 (7): 2076–81. PMID 12097696. http://jn.nutrition.org/cgi/pmidlookup?view=long&pmid=12097696.
- ^ Kimura Y, Okuda H (June 2001). “Resveratrol isolated from Polygonum cuspidatum root prevents tumor growth and metastasis to lung and tumor-induced neovascularization in Lewis lung carcinoma-bearing mice”. J. Nutr. 131 (6): 1844–9. PMID 11385077. http://jn.nutrition.org/cgi/pmidlookup?view=long&pmid=11385077.
- ^ Li ZG, Hong T, Shimada Y, Komoto I, Kawabe A, Ding Y, Kaganoi J, Hashimoto Y, Imamura M (2002). “Suppression of N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumorigenesis in F344 rats by resveratrol”. Carcinogenesis 23 (9): 1531–6. doi:10.1093/carcin/23.9.1531. PMID 12189197.
- ^ Wade, Nicholas (November 16 2006). “Red Wine Ingredient Increases Endurance, Study Shows”. New York Times.
- ^ Lagouge M, Argmann C, Gerhart-Hines Z, et al (2006). “Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha”. Cell 127 (6): 1109–22. doi:10.1016/j.cell.2006.11.013. PMID 17112576.
- ^ Karuppagounder SS, Pinto JT, Xu H, Chen HL, Beal MF, Gibson GE (November 2008). “Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer’s disease”. Neurochem Int.. doi:10.1016/j.neuint.2008.10.008. PMID 19041676.
- ^ Plant Antioxidant May Protect Against Radiation Exposure Science Daily September 24, 2008
- ^ Asensi M, Medina I, Ortega A, et al (August 2002). “Inhibition of cancer growth by resveratrol is related to its low bioavailability”. Free Radic. Biol. Med. 33 (3): 387–98. doi:10.1016/S0891-5849(02)00911-5. PMID 12126761. http://linkinghub.elsevier.com/retrieve/pii/S0891584902009115.
- ^ a b c d Walle T, Hsieh F, DeLegge MH, Oatis JE, Walle UK (2004). “High absorption but very low bioavailability of oral resveratrol in humans”. Drug Metab. Dispos. 32 (12): 1377–82. doi:10.1124/dmd.104.000885. PMID 15333514.
- ^ a b David J. Boocock, et al (2007). “Phase I Dose Escalation Pharmacokinetic Study in Healthy Volunteers of Resveratrol, a Potential Cancer Chemopreventive Agent”. Cancer Epidemiology Biomarkers & Prevention 16 (6): 1246–1252. doi:10.1158/1055-9965.EPI-07-0022. PMID 17548692.
- ^ Marier JF, Vachon P, Gritsas A, Zhang J, Moreau JP, Ducharme MP (2002). “Metabolism and disposition of resveratrol in rats: extent of absorption, glucuronidation, and enterohepatic recirculation evidenced by a linked-rat model”. J. Pharmacol. Exp. Ther. 302 (1): 369–73. doi:10.1124/jpet.102.033340. PMID 12065739.
- ^ Abd El-Mohsen M, Bayele H, Kuhnle G, et al (July 2006). “Distribution of [3H]trans-resveratrol in rat tissues following oral administration”. Br J Nutr. 96 (1): 62–70. doi:10.1079/BJN20061810. PMID 16869992.
- ^ Wenzel E, Soldo T, Erbersdobler H, Somoza V (May 2005). “Bioactivity and metabolism of trans-resveratrol orally administered to Wistar rats”. Mol Nutr Food Res 49 (5): 482–94. doi:10.1002/mnfr.200500003. PMID 15779067.
- ^ Yu C, Shin YG, Chow A, et al (December 2002). “Human, rat, and mouse metabolism of resveratrol”. Pharm Res. 19 (12): 1907–14. doi:10.1023/A:1021414129280. PMID 12523673. http://www.kluweronline.com/art.pdf?issn=0724-8741&volume=19&page=1907.
- ^ Wang LX, Heredia A, Song H, et al (October 2004). “Resveratrol glucuronides as the metabolites of resveratrol in humans: characterization, synthesis, and anti-HIV activity”. J Pharm Sci 93 (10): 2448–57. doi:10.1002/jps.20156. PMID 15349955.
- ^ a b c d Goldberg DM, Yan J, Soleas GJ (February 2003). “Absorption of three wine-related polyphenols in three different matrices by healthy subjects”. Clin. Biochem. 36 (1): 79–87. doi:10.1016/S0009-9120(02)00397-1. PMID 12554065. http://linkinghub.elsevier.com/retrieve/pii/S0009912002003971.
- ^ Wenzel E, Somoza V (May 2005). “Metabolism and bioavailability of trans-resveratrol”. Mol Nutr Food Res 49 (5): 472–81. doi:10.1002/mnfr.200500010. PMID 15779070.
- ^ a b c Vitaglione P, Sforza S, Galaverna G, et al (May 2005). “Bioavailability of trans-resveratrol from red wine in humans”. Mol Nutr Food Res 49 (5): 495–504. doi:10.1002/mnfr.200500002. PMID 15830336.
- ^ Gehm BD, McAndrews JM, Chien PY, Jameson JL (December 1997). “Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor”. Proc. Natl. Acad. Sci. U.S.A. 94 (25): 14138–43. doi:10.1073/pnas.94.25.14138. PMID 9391166. PMC: 28446. http://www.pnas.org/cgi/pmidlookup?view=long&pmid=9391166.
- ^ Bowers JL, Tyulmenkov VV, Jernigan SC, Klinge CM (October 2000). “Resveratrol acts as a mixed agonist/antagonist for estrogen receptors alpha and beta”. Endocrinology 141 (10): 3657–67. doi:10.1210/en.141.10.3657. PMID 11014220. http://endo.endojournals.org/cgi/pmidlookup?view=long&pmid=11014220.
- ^ Levi F, Pasche C, Lucchini F, Ghidoni R, Ferraroni M, La Vecchia C (April 2005). “Resveratrol and breast cancer risk”. Eur J Cancer Prev. 14 (2): 139–42. doi:10.1097/00008469-200504000-00009. PMID 15785317. http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0959-8278&volume=14&issue=2&spage=139.
- ^ Garvin S, Ollinger K, Dabrosin C (January 2006). “Resveratrol induces apoptosis and inhibits angiogenesis in human breast cancer xenografts in vivo”. Cancer Lett. 231 (1): 113–22. doi:10.1016/j.canlet.2005.01.031. PMID 16356836.
- ^ Bråkenhielm E, Cao R, Cao Y (August 2001). “Suppression of angiogenesis, tumor growth, and wound healing by resveratrol, a natural compound in red wine and grapes”. Faseb J. 15 (10): 1798–800. doi:10.1096/fj.01-0028fje. PMID 11481234. http://www.fasebj.org/cgi/pmidlookup?view=long&pmid=11481234.
- ^ More resveratrol information, What is Resveratrol?.
- ^ Lagouge M, Argmann C, Gerhart-Hines Z, et al (December 2006). “Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α”. Cell 127 (6): 1109–22. doi:10.1016/j.cell.2006.11.013. PMID 17112576.
- ^ Kaeberlein M, Kirkland KT, Fields S, Kennedy BK (September 2004). “Sir2-independent life span extension by calorie restriction in yeast”. PLoS Biol. 2 (9): E296. doi:10.1371/journal.pbio.0020296. PMID 15328540.
- ^ Kaeberlein M, McDonagh T, Heltweg B, et al (April 2005). “Substrate-specific activation of sirtuins by resveratrol”. J Biol Chem. 280 (17): 17038–45. doi:10.1074/jbc.M500655200. PMID 15684413.
- ^ Robb EL, Page MM, Wiens BE, Stuart JA (March 2008). “Molecular mechanisms of oxidative stress resistance induced by resveratrol: Specific and progressive induction of MnSOD”. Biochem Biophys Res Commun. 367 (2): 406–12. doi:10.1016/j.bbrc.2007.12.138. PMID 18167310.
- ^ Zsolt Radák, Free Radicals in Exercise and Aging, 2000, p39
- ^ Macmillan-Crow LA, Cruthirds DL (April 2001). “Invited review: manganese superoxide dismutase in disease”. Free Radic Res. 34 (4): 325–36. doi:10.1080/10715760100300281. PMID 11328670.
- ^ Cullen JJ, Weydert C, Hinkhouse MM, et al (15 March 2003). “The role of manganese superoxide dismutase in the growth of pancreatic adenocarcinoma”. Cancer Res. 63 (6): 1297–303. PMID 12649190. http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=12649190.
- ^ “Mounting Evidence Shows Red Wine Antioxidant Kills Cancer”, Department of Radiation Oncology, University of Rochester Medical Center. (2008-03-26). Retrieved on 26 March 2008.
- ^ Sun J, Folk D, Bradley TJ, Tower J (01 June 2002). “Induced overexpression of mitochondrial Mn-superoxide dismutase extends the life span of adult Drosophila melanogaster”. Genetics 161 (2): 661–72. PMID 12072463. PMC: 1462135. http://www.genetics.org/cgi/pmidlookup?view=long&pmid=12072463.
- ^ Hu D, Cao P, Thiels E, et al (March 2007). “Hippocampal long-term potentiation, memory, and longevity in mice that overexpress mitochondrial superoxide dismutase”. Neurobiol Learn Mem 87 (3): 372–84. doi:10.1016/j.nlm.2006.10.003. PMID 17129739.
- ^ Wong GH (May 1995). “Protective roles of cytokines against radiation: induction of mitochondrial MnSOD”. Biochim. Biophys. Acta 1271 (1): 205–9. PMID 7599209.
- ^ Stefani M, Markus MA, Lin RC, Pinese M, Dawes IW, Morris BJ (October 2007). “The effect of resveratrol on a cell model of human aging”. Ann N Y Acad Sci. 1114: 407–18. doi:10.1196/annals.1396.001. PMID 17804521.
- ^ Brunet A, Sweeney LB, Sturgill JF, et al (March 2004). “Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase”. Science 303 (5666): 2011–5. doi:10.1126/science.1094637. PMID 14976264.
- ^ Kops GJ, Dansen TB, Polderman PE, et al (September 2002). “Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress”. Nature 419 (6904): 316–21. doi:10.1038/nature01036. PMID 12239572.
- ^ Leiro J, Arranz JA, Fraiz N, Sanmartín ML, Quezada E, Orallo F (2005). “Effect of cis-resveratrol on genes involved in nuclear factor kappa B signaling”. Int. Immunopharmacol. 5 (2): 393–406. doi:10.1016/j.intimp.2004.10.006. PMID 15652768.
- ^ Chun YJ, Kim MY, Guengerich FP (1999). “Resveratrol is a selective human cytochrome P450 1A1 inhibitor”. Biochem. Biophys. Res. Commun. 262 (1): 20–4. doi:10.1006/bbrc.1999.1152. PMID 10448061.
- ^ Schwarz D, Roots I (2003). “In vitro assessment of inhibition by natural polyphenols of metabolic activation of procarcinogens by human CYP1A1”. Biochem. Biophys. Res. Commun. 303 (3): 902–7. doi:10.1016/S0006-291X(03)00435-2. PMID 12670496.
- ^ a b Benitez DA, Pozo-Guisado E, Alvarez-Barrientos A, Fernandez-Salguero PM, Castellon EA (October 18 2006). “Mechanisms involved in resveratrol-induced apoptosis and cell cycle arrest in prostate cancer-derived cell lines”. Journal of Andrology 28: 282. doi:10.2164/jandrol.106.000968. PMID 17050787.
- ^ Faber AC, Chiles TC (December 2006). “Resveratrol induces apoptosis in transformed follicular lymphoma OCI-LY8 cells: Evidence for a novel mechanism involving inhibition of BCL6 signaling”. International Journal of Oncology 29 (6): 1561–6. PMID 17088997.
- ^ Riles WL, Erickson J, Nayyar S, Atten MJ, Attar BM, Holian O (21 September 2006). “Resveratrol engages selective apoptotic signals in gastric adenocarcinoma cells”. World Journal of Gastroenterology 12 (35). PMID 17007014.
- ^ Sareen D, van Ginkel PR, Takach JC, Mohiuddin A, Darjatmoko SR, Albert DM, Polans AS (September 2006). “Mitochondria as the primary target of resveratrol-induced apoptosis in human retinoblastoma cells”. Investigative Ophthamology & Visual Science 47 (9). PMID 16936077.
- ^ Tang HY, Shih A, Cao HJ, Davis FB, Davis PJ, Lin HY (August 2006). Resveratrol-induced cyclooxygenase-2 facilitates p53-dependent apoptosis in human breast cancer cells. 5. PMID 16928824.
- ^ Aziz MH, Nihal M, Fu VX, Jarrard DF, Ahmad N (May 2006). “Resveratrol-caused apoptosis of human prostate carcinoma LNCaP cells is mediated via modulation of phosphatidylinositol 3′-kinase/Akt pathway and Bcl-2 family proteins”. Molecular Cancer Therapeutics 5 (5): 1335. doi:10.1158/1535-7163.MCT-05-0526. PMID 16731767.
- ^ Cao Y, Fu ZD, Wang F, Liu HY, Han R (2005). “Anti-angiogenic activity of resveratrol, a natural compound from medicinal plants”. Journal of Asian natural products research 7 (3): 205–13. doi:10.1080/10286020410001690190. PMID 15621628.
- ^ Hung LM, Chen JK, Huang SS, Lee RS, Su MJ (2000). “Cardioprotective effect of resveratrol, a natural antioxidant derived from grapes”. Cardiovasc. Res. 47 (3): 549–55. doi:10.1016/S0008-6363(00)00102-4. PMID 10963727.
- ^ Parker JA, Arango M, Abderrahmane S, et al (April 2005). “Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons”. Nat Genet. 37 (4): 349–50. doi:10.1038/ng1534. PMID 15793589.
- ^ Marambaud P, Zhao H, Davies P (November 2005). “Resveratrol promotes clearance of Alzheimer’s disease amyloid-beta peptides”. J Biol Chem. 280 (45): 37377–82. doi:10.1074/jbc.M508246200. PMID 16162502.
- ^ Olson ER, Naugle JE, Zhang X, Bomser JA, Meszaros JG (March 2005). “Inhibition of cardiac fibroblast proliferation and myofibroblast differentiation by resveratrol”. Am J Physiol Heart Circ Physiol. 288 (3): H1131–8. doi:10.1152/ajpheart.00763.2004. PMID 15498824.
- ^ Juan ME, González-Pons E, Munuera T, Ballester J, Rodríguez-Gil JE, Planas JM (2005). “trans-Resveratrol, a natural antioxidant from grapes, increases sperm output in healthy rats”. J Nutr. 135 (4): 757–60. PMID 15795430.
- ^ Bhat KP, Lantvit D, Christov K, Mehta RG, Moon RC, Pezzuto JM (2001). “Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models”. Cancer Res. 61 (20): 7456–63. PMID 11606380.
- ^ Wang Y, Lee KW, Chan FL, Chen S, Leung LK (2006). “The red wine polyphenol resveratrol displays bilevel inhibition on aromatase in breast cancer cells”. Toxicol Sci. 92 (1): 71–7. doi:10.1093/toxsci/kfj190. PMID 16611627.
- ^ Leder BZ, Rohrer JL, Rubin SD, Gallo J, Longcope C (2004). “Effects of aromatase inhibition in elderly men with low or borderline-low serum testosterone levels”. J Clin Endocrinol Metab 89 (3): 1174–80. doi:10.1210/jc.2003-031467. PMID 15001605.
- ^ Kode A, Rajendrasozhan S, Caito S, Yang SR, Megson IL, Rahman I (March 2008). “Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells”. Am J Physiol Lung Cell Mol Physiol. 294 (3): L478–88. doi:10.1152/ajplung.00361.2007. PMID 18162601.
- ^ Lamuela-Raventos, RM (1995). “Direct HPLC Analysis of cis- and trans-Resveratrol and Piceid Isomers in Spanish Red Vitis vinifera Wines” ([dead link] – Scholar search). J. Agric. Food Chem. (pubs.acs.org) 43 (43): 281–283. doi:10.1021/jf00050a003. http://pubs.acs.org/cgi-bin/abstract.cgi/jafcau/1995/43/i02/f-pdf/f_jf00050a003.pdf?sessid=6006l3.
- ^ Prokop J, Abrman P, Seligson AL, Sovak M (2006). “Resveratrol and its glycon piceid are stable polyphenols”. J Med Food 9 (1): 11–4. doi:10.1089/jmf.2006.9.11. PMID 16579722.
- ^ Bertelli AA, Gozzini A, Stradi R, Stella S, Bertelli A (1998). “Stability of resveratrol over time and in the various stages of grape transformation”. Drugs Exp Clin Res 24 (4): 207–11. PMID 10051967.
- ^ a b c d e Roy, H., Lundy, S., Resveratrol, Pennington Nutrition Series, 2005 No. 7
- ^ a b c d e LeBlanc, Mark Rene (2005-12-13). “Cultivar, Juice Extraction, Ultra Violet Irradiation and Storage Influence the Stilbene Content of Muscadine Grapes (Vitis Rotundifolia Michx.)”. Retrieved on 2007-08-15.
- ^ Gu X, Creasy L, Kester A, Zeece M (August 1999). “Capillary electrophoretic determination of resveratrol in wines”. J Agric Food Chem. 47 (8): 3223–7. doi:10.1021/jf981211e. PMID 10552635.
- ^ Ector BJ, Magee JB, Hegwood CP, Coign MJ., Resveratrol Concentration in Muscadine Berries, Juice, Pomace, Purees, Seeds, and Wines.
- ^ Pastrana-Bonilla E, Akoh CC, Sellappan S, Krewer G (August 2003). “Phenolic content and antioxidant capacity of muscadine grapes”. J. Agric. Food Chem. 51 (18): 5497–503. doi:10.1021/jf030113c. PMID 12926904. “Contrary to previous results, ellagic acid and not resveratrol was the major phenolic in muscadine grapes. The HPLC solvent system used coupled with fluorescence detection allowed separation of ellagic acid from resveratrol and detection of resveratrol.” “trans-resveratrol had the lowest concentrations of the detected phenolics, ranging from not detected in two varieties to 0.2 mg/ 100 g of FW (Tables 1 and 2). Our result for resveratrol differed from previous results [Ector et al., 1996] indicating high concentrations. These researchers apparently were not able to separate ellagic acid from resveratrol with UV detection alone.”.
- ^ Hudson TS, Hartle DK, Hursting SD, et al (September 2007). “Inhibition of prostate cancer growth by muscadine grape skin extract and resveratrol through distinct mechanisms”. Cancer Res. 67 (17): 8396–405. doi:10.1158/0008-5472.CAN-06-4069. PMID 17804756. “MSKE [muscadine grape skin extract] does not contain significant quantities of resveratrol and differs from MSEE. To determine whether MSKE contains significant levels of resveratrol and to compare the chemical content of MSKE (skin) with MSEE (seed), HPLC analyses were done. As depicted in Supplementary Fig. S1A and B, MSKE does not contain significant amounts of resveratrol (<1 ?g/g by limit of detection).”.
- ^ Stewart JR, Artime MC, O’Brian CA (01 July 2003). “Resveratrol: a candidate nutritional substance for prostate cancer prevention”. J Nutr. 133 (7 Suppl): 2440S–2443S. PMID 12840221. http://jn.nutrition.org/cgi/content/full/133/7/2440S.
- ^ Mozzon, M. (1996). “Resveratrol content in some Tuscan wines”. Ital. J. Food sci. (Chiriotti, Pinerolo, ITALIE) 8 (2): 145–52. http://cat.inist.fr/?aModele=afficheN&cpsidt=3123149. Retrieved on 18 June 2007.
- ^ a b Stervbo, U.; Vang, O.; Bonnesen, C. (2007). “A review of the content of the putative chemopreventive phytoalexin resveratrol in red wine”. Food Chemistry 101 (2): 449–57. doi:10.1016/j.foodchem.2006.01.047.
- ^ Higdon, Jane (2005). “Resveratrol”. Oregon State University. The Linus Pauling Institute Micronutrient Information Center. Retrieved on 2007-06-18.
- ^ “Resveratrol”. The Peanut Institute (1999). Retrieved on 2008-01-28.
- ^ Wang Y, Catana F, Yang Y, Roderick R, van Breemen RB (2002). “An LC-MS method for analyzing total resveratrol in grape juice, cranberry juice, and in wine”. J. Agric. Food Chem. 50 (3): 431–5. doi:10.1021/jf010812u. PMID 11804508.
- ^ Lyons MM, Yu C, Toma RB, et al (2003). “Resveratrol in raw and baked blueberries and bilberries”. J. Agric. Food Chem. 51 (20): 5867–70. doi:10.1021/jf034150f. PMID 13129286.
- ^ Rimas, Andrew (2006-12-11). “MOLECULAR BIOLOGIST DAVID SINCLAIR, MEETING THE MINDS”, Boston Globe, boston.com. Retrieved on 22 June 2007.
- ^ Stipp, David (2007-01-19). “Can red wine help you live forever?”, Fortune magazine, CNN, pp. 3. Retrieved on 15 August 2007.
- ^ “MM2 Group Announces Record Sales of Its Resveratrol Grape Powder”, MM2 Group, Earthtimes.org (2006-11-29). Retrieved on 22 June 2007.
- ^ a b Zachary M. Seward (2006-11-30). “Quest for youth drives craze for ‘wine’ pills” (htm). The Wall Street Journal. Retrieved on 2008-02-02.
- ^ “Caution urged with resveratrol”, United Press International, Upi.com (2006-11-30). Retrieved on 21 June 2007.
- ^ Aleccia, JoNel (2008-04-22). “Longevity quest moves slowly from lab to life”, MSNBC, msnbc.com. Retrieved on 22 April 2008.
- ^ Scientists Develop Life-Extending Compounds
- ^ Scientists Locate Revved Up Chemical That Mimics Red Wine
- ^ R. Corder et al., Oenology: Red wine procyanidins and vascular health., Nature vol. 444, p. 566; 30 November 2006.